Amlodipine and valsartan as components of a rational and effective fixed-dose combination
نویسندگان
چکیده
منابع مشابه
Amlodipine and valsartan as components of a rational and effective fixed-dose combination
Pharmacological treatment of hypertension is effective in preventing cardiovascular and renal complications. Calcium antagonists and blockers of the renin-angiotensin system are widely used today to initiate antihypertensive therapy but, when given as monotherapy, do not suffice in most patients to normalize blood pressure. Combining the two types of agents considerably increases the antihypert...
متن کاملFixed-dose combination Therapy in Hypertension: Focus on Fixed-dose combination of Amlodipine and Valsartan (exforge®)
Hypertension is the leading cause of disability and cardiovascular mortality world-wide. Approximately one-third of the US adult population and over a billion people world-wide have hypertension. Despite increased awareness of hypertension and availability of many effective antihypertensive agents, only one third of patients achieve their target blood pressure (BP). All expert panels now recomm...
متن کاملComparison of amlodipine/valsartan fixed-dose combination therapy and conventional therapy.
PURPOSE Single-pill-combination (SPC) antihypertensive drug products have been shown to improve compliance but are associated with higher acquisition costs. This study compared the clinical and economic outcomes associated with the use of an SPC of amlodipine/valsartan (trade name Exforge) with the outcomes from conventional combination therapy in patients failing to respond to initial monother...
متن کاملThe effect of fixed-dose combination of valsartan and amlodipine on nighttime blood pressure in patients with non-dipper hypertension.
OBJECTIVE Failure to decrease blood pressure (BP) during the night is associated with higher cardiovascular (CV) morbidity and mortality. There is strong evidence that fixed-dose combinations (FDCs) of antihypertensive agents are associated with significant improvement and non-significant adverse effects. The aim of the present study was to evaluate whether FDC affected nocturnal BP favorably i...
متن کاملRole of valsartan, amlodipine and hydrochlorothiazide fixed combination in blood pressure control: an update
The treatment of moderate or severe hypertension in most cases requires the contemporaneous use of multiple antihypertensive agents. The most available two-drug combinations have an agent that addresses renin secretion and another one that is statistically more effective in renin-independent hypertension. The practice of combining agents that counteract different mechanisms is the most likely e...
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ژورنال
عنوان ژورنال: Vascular Health and Risk Management
سال: 2009
ISSN: 1178-2048
DOI: 10.2147/vhrm.s3134